Journal: Life
Article Title: Melatonin Prevents UVB-Induced Skin Photoaging by Inhibiting Oxidative Damage and MMP Expression through JNK/AP-1 Signaling Pathway in Human Dermal Fibroblasts
doi: 10.3390/life12070950
Figure Lengend Snippet: Representation of melatonin’s effects on UVB-induced skin photoaging. UV, ultraviolet; EGFR: epidermal growth factor receptor; ROS: reactive oxygen species; MDA, malondialdehyde; GSSG/GSH, oxidized/reduced glutathione; JNK, c-Jun amino-terminal kinase; AP-1, activator protein-1; MMP-1, matrix metalloproteinase-1; MMP-3, matrix metalloproteinase-3; TIMP-1, tissue inhibitor of metalloproteinase-1; PIPC, type I procollagen.
Article Snippet: The transcriptional activity of AP-1 (c-Jun/c-Fos) was detected by highly sensitive ELISA-based TransAM AP-1 c-Fos/c-Jun transcription factor assay kits (Active Motif, Carlsbad, CA, USA) according to the manufacturer’s instructions.
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